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250-511 exam Dumps Source : Administration of Symantec(TM) Data Loss(R) Prevention 11

Test Code : 250-511
Test designation : Administration of Symantec(TM) Data Loss(R) Prevention 11
Vendor designation : Symantec
: 176 actual Questions

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Symantec Administration of Symantec(TM) Data

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First identify: ultimate name: electronic mail tackle: Password: ascertain Password: Username:

Title: C-level/President manager VP carcass of workers (associate/Analyst/and many others.) Director

feature:

position in IT decision-making technique: Align enterprise & IT dreams Create IT mode check IT needs control seller Relationships evaluate/Specify brands or providers different role accredit Purchases now not involved

Work phone: enterprise: enterprise dimension: business: highway handle city: Zip/postal code State/Province: nation:

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Google Chrome 70 is coming. Are your safety certificates so as? | killexams.com actual Questions and Pass4sure dumps

previous this yr, I wrote about what security professionals should accomplish to do together for the upcoming Google distrust time limit. I renowned that DigiCert had taken a number of steps that ended in a smooth process this spring for the first of two distrust dates. they now relish yet another date drawing near when Google Chrome 70 will distrust utter TLS certificates issued from the Symantec PKI.

Given what I’ve discovered from DigiCert, I suppose confident that DigiCert is managing the Chrome 70 process easily this time round, too.

Plan to piece out Symantec certificates

For those unfamiliar with the particulars of this, in 2017 Google and Mozilla decided to deprecate utter Symantec-issued digital certificates according to their assessment that Symantec didn't as it should breathe validate its SSL certificates previous to issuing them to shoppers.

Google and Mozilla then decided to plot in location a multi-step intention to mistrust any certificates issued from the Symantec PKI. This intention phased out Symantec certificates over the subsequent yr and a half. as an alternative of following the Google plan, Symantec elected to promote its certificates enterprise to DigiCert. regardless of the transaction, the requirement to supplant utter certificates issued from the Symantec PKI remained intact, requiring hundreds of thousands of certificates to tangle replaced during 2018. To aid valued clientele in changing their certificates, DigiCert contacted every certificates holder, providing free replacement certificates chained to the trusted DigiCert roots.

the first most principal mistrust date changed into on December 1, 2017, when no extra TLS certificates can breathe issued during the Symantec PKI. earlier than that date, DigiCert slash over utter issuance techniques to its PKI and validation methods. The next predominant mistrust date changed into March 15, 2018, when Chrome 66 beta distrusted utter Symantec TLS certificates issued earlier than June 1, 2016. 

The final predominant step in this distrust event is scheduled for Oct. sixteen, 2018, when Chrome 70 suitable will mistrust utter TLS certificates issued from the Symantec PKI. (This date might also alternate in accordance with Google’s release time table.) Upon release of Chrome 70, any web page nevertheless the exercise of a Symantec certificates may relish an interstitial warning a yoke of non-private connection.

HTTPS is now in utter places, making certificates compliance obligatory

regularly occurring lore was once that handiest sites that deal with economic or other sensitive facts required certificates, however instances relish changed. today over 80 p.c of net site visitors is “https”, which contains many basis pages. there has been a speedy pressure to https utter over the place, and it won’t breathe long when basically every page is comfortable.

Google is ushering that along. Chrome now marks utter HTTP net pages as “now not comfy” in the browser address bar. also, notwithstanding the web site is monitor handiest, the warning clients will see may scare them off and occasions them talk over with a competitor, so it’s something utter safety specialists that manage sites may silent breathe concerned about. 

different platforms additionally crack down on Symantec certificates

It’s crucial to note that despite the fact Chrome 70 is the plot the instant challenge is, other platforms will breathe doing the very issue with Symantec-issued certificates. Mozilla's date is across the equal time as Chrome's, however the user basis is a suitable deal smaller. Apple has not issued a final date, however the primary angle has been accomplished, so older certificates won’t work. Microsoft nonetheless has no introduced date, however the business has incredible controls for the mistrust difficulty, so there should silent no longer breathe plenty of an affect in the beginning.

conform to Chrome distrust now

My assistance to safety leaders is to focus on the rigor now, forward of the Chrome date. Google had essentially the most aggressive date, so complying with Chrome mistrust skill the other dates down the street won’t breathe of rigor as a result of a compliant certificates will breathe in vicinity. I mentioned this before, but it surely’s cost reiterating that here is whatever utter businesses should silent conform to inspite of the intention of the web page. 

companies that relish a tremendous number of websites might locate this a rigorous system as a result of changing certificates manually can breathe time-drinking, tedious, and filled with mistake because of the variety of steps involved. DigiCert has do a yoke of automation apparatus in location to merit the system of checking and upgrading convenient. It is rarely full automation, as a yoke of usher steps are required, however the technique of relocating from the non-compliant Symantec certificates to a present one is enormously more convenient than before, so complexity is not any longer a barrier.

DigiCert has completed a suitable job disposing of any obstacles to doing a free alternative with them. They’ve managed to simplify the process right down to a pair clicks in a client internet portal, akin to how an administrator would renew a certificate about to elope out.

I checked in with DigiCert, the brand modern owner of the Symantec CA company, on how the upgrade of the Symantec consumer basis has gone. to this point, about ninety nine % of the Alexa 1 million (which makes up the huge majority of web traffic) basis domains relish been changed devoid of difficulty. the majority of utter impacted certificates are reissued or in technique. The past dates relish Come and gone devoid of concern, and i await an analogous outcomes with the remaining step developing in mid-October.


Symantec warns of China-based mostly espionage crusade concentrated on satellites | killexams.com actual Questions and Pass4sure dumps

A China-based cyber community is accomplishing an in depth hacking crusade by means of concentrated on satellite tv for pc, telecom and defense companies within the u.s. and Southeast Asia, a U.S. cybersecurity hard warned this week.

The purpose of the hacking community, referred to as "Thrip," is likely national cyber espionage, security researchers at Symantec Corp. spoke of on Tuesday.

"Thrip’s assault on telecoms and satellite tv for pc operators exposes the opening that the attackers may intercept and even alter communications site visitors from agencies and consumers," Symantec observed in a statement, including that the most stressful discovery is an try and manage satellites via infecting linked computers with malware.

commercial

"The assault group seemed to breathe notably interested in the operational facet of the company, hunting for and infecting computer systems operating utility that displays and controls satellites. this suggests to us that Thrip’s motives fling past spying and may additionally involve disruption," Symantec wrote in a separate blog publish.

Satellites play a primary position in telecommunications, receiving and transmitting phone and cyber web alerts in addition to mapping and geolocation information.

Symantec said in Tuesday's remark that it has tracked Thrip seeing that 2013 and currently accompanied that the cyber community seems to relish "discovered modern tools and innovations used by the community during this most synchronous set of attacks."

The possibility of the more advantageous hacking toolbox is further compounded via Thrip's means to reside smartly hidden.

"They function very quietly, mixing in to networks, and are handiest found out using ersatz intelligence that may determine and flag their movements," Symantec Chief executive Greg Clark referred to in a press release.

The business says it found out the modern assaults through its ersatz intelligence-primarily based targeted beset Analytics, which helped the researchers spot the malicious conduct that was hiding in legitimate IT administration tools.




Killexams.com 250-511 Dumps and actual Questions

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250-511 exam Dumps Source : Administration of Symantec(TM) Data Loss(R) Prevention 11

Test Code : 250-511
Test designation : Administration of Symantec(TM) Data Loss(R) Prevention 11
Vendor designation : Symantec
: 176 actual Questions

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Administration of Symantec(TM) Data Loss(R) Prevention 11

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Cyber Security Market in Depth Professional Survey Report 2018-2022 | killexams.com actual questions and Pass4sure dumps

(MENAFN Editorial) iCrowdNewswire - Sep 18, 2018

The Global Cyber Security Market was worth USD 58.13 billion in the year 2012 and is expected to compass approximately USD 173.57 billion by 2022, while registering itself at a compound annual growth rate (CAGR) of 10.35% during the forecast period.

Cyber Security - Top Major Market Players:

The major players in the market are Symantec Software Solutions Private Limited, Trend Micro, Cisco Systems, Check Point Software Technologies and Fortinet Inc.

Sample Copy of the Report here @ www.crystalmarketresearch.com/report-sample/IC10289 .

Cyber security is the group of practices, technologies and procedures intended to ensure data, networks, programs and computers from attacks, unauthorized access or damage. Security incorporates both cyber security and physical security in computing context. Guaranteeing cyber security requires composed endeavors utter through a data framework. A standout amongst the trickiest components of cyber security is the constantly and rapidly developing nature of security dangers. The conventional approach has been to concentrate most assets on the most vital framework segments and secure against the greatest known dangers, which required abandoning some less essential framework parts undefended and some less unsafe dangers not ensured against. Such an approach is deficient in the present condition.

The emergence of cloud storage has increased the chances of data breaches and cybercrimes. The institution of Internet of Things (IoT) is opening up beset surfaces, using vulnerabilities for network frameworks. This is bringing about the adoption of remote and endpoint security being one of the prime factors that influence the progress of the cyber security market. The emerging economies, for example, China, India, Hong Kong, South Korea, and, relish tall motivating forces in consolidating their IT structures.

The Global Cyber Security market is segmented as follows:

Cyber Security - By Region:

North America - U.S, Canada, MexicoEurope - Germany, France, UK, Italy, Spain, ease of EuropeAsia-Pacific - Japan, China, Australia, India, South Korea, ease of Asia PacificRest of the World - Brazil, South Africa, Saudi Arabia, United Arab Emirates, Others

Cyber Security - Regional Outlook and Trend Analysis:

In 2015 Asia Pacific represented more than 21 percent partake of the global industry. The expanding dependence on the Internet has expanded vulnerabilities, giving chances to programmers and assailants. South Korea, Singapore, and Singapore relish expanded the extent of their cyber policy structure and the viability of their execution. Nonetheless, nations, for example, Australia, India, and China are concentrating on bringing together the organization of the cyber policy under the government divisions. Latin America is expected to breathe a developing locale over the gauge time frame. The belt has one of the most elevated penetrations of cell phones prompting vulnerabilities for digital assaults as these gadgets are a simple focus for malware attack, stressing the requirement for the advancement of compelling cybercrime security and policies.

Cyber Security - Service Outlook and Trend Analysis

Security models are being outsourced by associations to third party suppliers inferable from lacking security experts in-house, hence boosting the progress of security benefits over the assess time frame. Rising demand for cloud-based security administrations to diminish costs and enhance profitability is anticipated to drive the progress of security services over the pattern time frame. Managed services are anticipated to relish a tall progress attributable to the expanding dangers from regular extremist exercises. The rising government expenditure for the usage of cyber security arrangements in India and China is boosting the progress of security services.

Cyber Security - By Component:

SolutionsUnified threat managementIDS/IPSData Loss Prevention (DLP)

Identity Access Management (IAM)Security Information and Event Management (SIEM)Distributed Denial of Service (DDoS)Risk and compliance managementOther Solutions

ServicesProfessional servicesManaged services

Cyber Security - By Security Type:

Enterprise securityCloud securityNetwork securityApplication securityOther Security Types

Cyber Security - By Deployment:

CloudOn-premise

Cyber Security - By Organization:

Small and medium enterprisesLarge enterprises

Cyber Security - By Application:

IT & TelecomBFSIRetailHealthcareAutomotiveDefense/governmentOther Applications

For more information, click on the below link @ www.crystalmarketresearch.com/report/cyber-security-market .

Cyber Security - Application Outlook and trend Analysis

The BFSI section is anticipated to encounter a solid progress in the cyber security market in the upcoming years. The segment is expanding its cyber security expenditure in light of the developing breaches and risks. The expanded utilization of versatility channels for fiscal transactions and correspondence is expanding the susceptibility for cyberattacks. Banks relish actualized a two-factor confirmation for online and mobile banking, which has a tall exposure to threats because of the risks relish loss of gadget and frail passwords. The defense/government segment is changing progressively as dangers from regular exercises are not any more the main concerns. The assignment of resources for growing investment and research and progress of defense programs are foreseen to remain the key patterns in the cyber security industry. For example, the United States President proposed a fiscal intention of USD 14 billion for 2016 for the digital security endeavors over the administration to shield the private and government systems from cyber assaults.

Read Premium news from OpenPR of 'Cyber Security Market @ https://www.openpr.com/news/1244743/Cyber-Security-Market-Development-Strategy-CAGR-10-35-forecasted-period-2018-2022-Symantec-Software-Solutions-Private-Limited-Trend-Micro-Cisco-Systems-Check-Point-Software-Technologies-and-Fortinet-Inc.html .

Cyber Security - Table of Contents:

1.Introduction

2.Executive Summary

3.Market Overview

4.Cyber Security Market, By Component4.1.Introduction4.2.The Cyber Security Market Assessment and Forecast, By Component, 2012-20224.3.Solutions4.4.Services5.Cyber Security Market, By Security Type5.1.Introduction5.2.The Cyber Security Market Assessment and Forecast, By Security ilk 2012-20225.3.Enterprise security5.4.Cloud security5.5.Network security5.6.Application security5.7.Other Security Types…

Key findings of the Cyber Security Market:

The healthcare segment is anticipated to encounter significant progress in the upcoming years. The health insurers are the prime focus of the cyber assaults relish spear phishing and Advanced Persistent Threats (APTs). The violations and breaks in this belt are ascending as the cost of stolen medical record is expanding.

The rising requirement for Security-as-a-Service (SaaS) and cloud-based solutions is anticipated to render growth opportunities to the service segment.

The North American cyber security industry is foreseen to develop at substantial pace in the following years. The expanding cybercrime costs are empowering the district to concentrate on building a solid energy framework for dealing with cybercrimes.

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TherapeuticsMD Announces Multiple Presentations Related to Imvexxy™ and TX-001HR at the 2018 Annual Meeting of the North American Menopause Society | killexams.com actual questions and Pass4sure dumps

BOCA RATON, Fla.--(Business Wire)--TherapeuticsMD, Inc. (NASDAQ: TXMD), an innovative women’s healthcare company, today announced the schedule of ten oral presentations and posters at NAMS 2018, the annual meeting of the North American Menopause Society being held in San Diego, California on October 3-6, 2018, related to ImvexxyTM (estradiol vaginal inserts) and TX-001HR, the Company’s investigational bio-identical hormone therapy combination of estradiol and progesterone in a single, oral softgel for the treatment of moderate-to-severe vasomotor symptoms due to menopause.

There will breathe three oral presentations reviewing the findings of the angle 3 Replenish trial of TX-001HR and the systemic profile of Imvexxy (TX-004HR).

“We are pleased to present additional data from the Replenish trial that further support the safety and efficacy of TX-001HR as the first bio-identical combination hormone therapy of estradiol and progesterone,” said TherapeuticsMD Chief Medical Officer Sebastian Mirkin, M.D. “The FDA PDUFA target action date for TX-001HR is October 28, 2018. If approved, TX-001HR would provide an FDA-approved treatment option for the millions of postmenopausal women who are currently seeking treatment for qualify to strict vasomotor symptoms using unapproved compounded hormones.”

The posters and presentations will breathe made available on the Investors & Media section of the company’s website at www.therapeuticsmd.com.

 

Oral Presentations

  Date:         October 4, 2018 Time: 4:45-5:00 pm Title:

Effects of Single-Capsule 17β-Estradiol/Progesterone (TX-001HR) on Metabolic Parameters and Cardiovascular Outcomes in Menopausal Women of the REPLENISH Trial

  Date: October 5, 2018 Time: 4:15-4:30 pm Title: 17β-Estradiol/Progesterone in a Single, Oral, Softgel Capsule (TX-001HR) Significantly Increased the Number of Symptom-free Days in the REPLENISH Trial   Date: October 5, 2018 Time: 5:00-5:15 pm Title:

Evaluation of Systemic Effects of a Vaginal Estradiol Softgel Capsule (TX-004HR) in Menopausal Women with Moderate-to-Severe Dyspareunia

 

Posters

Date: October 4, 2018 Time: 6:00-7:00 pm   Title: Physical Characteristics of TX-004HR: An Ultra-Low-Dose (4- and 10-µg) Estradiol Softgel Capsule Vaginal Insert   Title: A 17β-Estradiol, Softgel, Vaginal Capsule (TX-004HR) Demonstrated an Early Onset of Action for Treating Vulvar and Vaginal Atrophy (VVA) and Moderate-to-Severe Dyspareunia   Title: Systemic Estradiol Levels with Low-Dose Vaginal Estrogens May disagree by Dose and by Product   Title: Correlations of Serum Estradiol and Estrone Concentrations with Menopausal Outcomes and Bleeding   Title: Effects of Single-Capsule 17β-Estradiol/Progesterone (TX-001HR) on Weight and Blood Pressure in Menopausal Women of the REPLENISH Trial   Title: Estradiol and Progesterone Bioavailability for Moderate-to-Severe Vasomotor Symptom Treatment and Endometrial Protection with the Continuous-Combined Regimen of TX-001HR (Oral Estradiol and Micronized Progesterone Capsules)   Title: TX-001HR is Associated with a Clinically Meaningful result on Severity of Moderate-to-Severe Vasomotor Symptoms in the REPLENISH Trial  

About Imvexxy

Imvexxy (estradiol vaginal inserts) is approved in the U.S. for the treatment of moderate-to-severe dyspareunia (vaginal pain associated with sexual activity), a symptom of vulvar and vaginal atrophy (VVA), due to menopause. Imvexxy is the only product in its therapeutic class to proffer a 4 mcg and 10 mcg dose, the 4 mcg dose representing the lowest approved dose of vaginal estradiol available. The full prescribing information may breathe viewed by visiting www.Imvexxy.com.

IMPORTANT SAFETY INFORMATION FOR IMVEXXY

  WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA

See full prescribing information for complete boxed warning.

Estrogen-Alone Therapy

• There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens

• Estrogen-alone therapy should not breathe used for the prevention of cardiovascular disease or dementia

• The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and profound vein thrombosis (DVT)

• The WHI remembrance Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older

 

Estrogen Plus Progestin Therapy

• Estrogen plus progestin therapy should not breathe used for the prevention of cardiovascular disease or dementia

• The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE) and myocardial infarction (MI)

• The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer

• The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older

 

CONTRAINDICATIONS

  • Imvexxy™ is contraindicated in women with any of the following conditions: undiagnosed abnormal genital bleeding; known, suspected, or history of breast cancer; known or suspected estrogen-dependent neoplasia; lively DVT, PE, or history of these conditions; lively arterial thromboembolic disease or a history of these conditions; known anaphylactic reaction or angioedema to Imvexxy; known liver impairment or disease; known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • WARNINGS AND PRECAUTIONS

  • Imvexxy is intended only for vaginal administration. Systemic absorption may occur with the exercise of Imvexxy.
  • The exercise of estrogen-alone and estrogen plus progestin therapy has been reported to result in an expand in abnormal mammograms requiring further evaluation.
  • The WHI estrogen plus progestin substudy reported a statistically non-significant increased risk of ovarian cancer. A meta-analysis of 17 prospective and 35 retrospective epidemiology studies found that women who used hormonal therapy for menopausal symptoms had an increased risk for ovarian cancer. The exact duration of hormone therapy exercise associated with an increased risk of ovarian cancer, however, is unknown.
  • Other warnings include: gallbladder disease; strict hypercalcemia, loss of vision, strict hypertriglyceridemia or cholestatic jaundice.
  • Estrogen therapy may occasions an exacerbation of asthma, diabetes mellitus, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas and should breathe used with caution in women with these conditions.
  • Women on thyroid replacement therapy should relish their thyroid function monitored.
  • ADVERSE REACTIONS

  • The most common adverse reaction with Imvexxy (incidence ≥ 3 percent) and greater than placebo was headache.
  • Please note that this information is not comprehensive. gratify visit www.Imvexxy.com for the full Prescribing Information, including the Boxed WARNING.

    About TherapeuticsMD, Inc.

    TherapeuticsMD, Inc. is an innovative healthcare company focused on developing and commercializing novel products exclusively for women. Their products are designed to address the unique changes and challenges women undergo through the various stages of their lives with a therapeutic focus in family planning, reproductive health, and menopause management. The company is committed to advancing the health of women and championing awareness of their healthcare issues. To learn more about TherapeuticsMD, gratify visit www.therapeuticsmd.com or follow us on Twitter: @TherapeuticsMD and on Facebook: TherapeuticsMD.

    Forward-Looking Statements

    This press release by TherapeuticsMD, Inc. may hold forward-looking statements. Forward-looking statements may include, but are not limited to, statements relating to TherapeuticsMD’s objectives, plans and strategies as well as statements, other than historical facts, that address activities, events or developments that the company intends, expects, projects, believes or anticipates will or may occur in the future. These statements are often characterized by terminology such as “believes,” “hopes,” “may,” “anticipates,” “should,” “intends,” “plans,” “will,” “expects,” “estimates,” “projects,” “positioned,” “strategy” and similar expressions and are based on assumptions and assessments made in light of management’s undergo and perception of historical trends, current conditions, expected future developments and other factors believed to breathe appropriate. Forward-looking statements in this press release are made as of the date of this press release, and the company undertakes no duty to update or revise any such statements, whether as a result of modern information, future events or otherwise. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties, many of which are outside of the company’s control. principal factors that could occasions actual results, developments and business decisions to disagree materially from forward-looking statements are described in the sections titled “Risk Factors” in the company’s filings with the Securities and Exchange Commission, including its most recent Annual Report on contour 10-K and Quarterly Reports on contour 10-Q, as well as reports on contour 8-K, and involve the following: whether the FDA will accredit the NDA for the company’s TX-001HR product candidate and whether such approval will occur by the PDUFA target action date; the company’s capacity to maintain or expand sales of its products; the company’s capacity to develop and commercialize IMVEXXYTM, ANNOVERATM and its hormone therapy drug candidates and obtain additional financing necessary therefor; whether the company will breathe able to comply with the covenants and conditions under its term loan agreement; the length, cost and uncertain results of the company’s clinical trials; the potential of adverse side effects or other safety risks that could preclude the approval of the company’s hormone therapy drug candidates or adversely affect the commercialization of the company’s current or future approved products; the company’s reliance on third parties to conduct its clinical trials, research and progress and manufacturing; the availability of reimbursement from government authorities and health insurance companies for the company’s products; the impact of product liability lawsuits; the influence of extensive and costly government regulation; the volatility of the trading cost of the company’s common stock and the concentration of power in its stock ownership. PDF copies of the company’s historical press releases and fiscal tables can breathe viewed and downloaded at its website: www.therapeuticsmd.com/pressreleases.aspx.

    TherapeuticsMD, Inc.Investor Contact:Nichol Ochsner, 561-961-1900, ext. 2088Vice President Investor RelationsNochsner@TherapeuticsMD.com


    ARCA biopharma Announces Second Quarter 2018 fiscal Results and Provides Corporate Update | killexams.com actual questions and Pass4sure dumps

    WESTMINSTER, Colo., Aug. 09, 2018 (GLOBE NEWSWIRE) -- ARCA biopharma, Inc. (ABIO), a biopharmaceutical company applying a precision medicine approach to developing genetically-targeted therapies for cardiovascular diseases, today reported fiscal results for the quarter ended June 30, 2018.

    “The second quarter of this year saw an principal milestone for the Gencaro progress program with the completion of an End-of-Phase 2 FDA meeting that provided principal guidance for the next steps in their progress of Gencaro as potentially the first genetically-targeted treatment for atrial fibrillation,” commented Dr. Michael Bristow, ARCA’s President and Chief Executive Officer.  “With toil underway on completing the Gencaro angle 3 trial protocol and continued progress with IND enabling activities for AB171 in PAD and HF, they believe ARCA is advancing their pipeline of genetically-targeted therapeutics to address the unmet medical needs of patients with cardiovascular disease.”

    Pipeline Update

    Gencaro (bucindolol hydrochloride) - a pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and confirmed heart failure with reduced left ventricular ejection fraction (HFrEF).

  • In April 2018, Medtronic, Inc. and ARCA agreed to extend their current U.S., Canadian and European Clinical trial Collaboration Agreement for one additional year.
  • In May 2018, results from ARCA’s GENETIC-AF angle 2B clinical trial were presented in a “Late Breaking Clinical Trials” oral presentation at the European Society of Cardiology (ESC) Heart Failure 2018 World Congress.
  • In June 2018, ARCA held an End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) to review the GENETIC-AF data and potential future Gencaro progress plans.
  • FDA concurrence to proceed into angle 3 was reached. ARCA anticipates submitting a Special Protocol Assessment (SPA) application for the proposed Gencaro angle 3 clinical trial in the third quarter of 2018. Progress to angle 3 is contingent on the Company receiving additional funding.
  • AB171 – a thiol-substituted isosorbide mononitrate being developed as a potential genetically-targeted treatment for heart failure (HF) and peripheral arterial disease (PAD).

  • Chemistry, manufacturing and controls (CMC) activities were continued in the second quarter.
  • IND-enabling non-clinical studies are anticipated to open in the first half of 2019.
  • Second Quarter 2018 Summary fiscal Results

    Cash, cash equivalents and marketable securities totaled $9.6 million as of June 30, 2018, compared to $11.8 million as of December 31, 2017. ARCA believes that its current cash, cash equivalents and marketable securities will breathe enough to fund its operations, at its projected cost structure, through the End of the first quarter of 2019.

    Research and progress (R&D) expenses for the quarter ended June 30, 2018 totaled $1.2 million compared to $4.5 million for the corresponding term of 2017.  The $3.3 million decrease in research and progress expenses in the second quarter of 2018 as compared to the second quarter 2017 was primarily due to decreased clinical expenses following the completion of the GENETIC-AF clinical trial.  The Company expects R&D expenses in 2018 to breathe lower than 2017 as the GENETIC-AF clinical trial has been completed.

    General and administrative (G&A) expenses for the quarter ended June 30, 2018 were $1.0 million, relatively unchanged compared to the $1.1 million in the second quarter of 2017.  ARCA expects G&A expenses in 2018 to breathe consistent with those in 2017 as it maintains administrative activities to support ongoing operations.

    Total operating expenses for the quarter ended June 30, 2018 were $2.2 million compared to $5.6 million for the second quarter of 2017.  The decrease in total operating expenses for the second quarter of 2018 was primarily due to the decrease in R&D expense due to the completion of the GENETIC-AF clinical trial.

    Net loss was $2.1 million, or $0.15 per share, for the second quarter of 2018 compared to $5.5 million, or $0.59 per share, for the second quarter of 2017.

    About ARCA biopharma

    ARCA biopharma is dedicated to developing genetically-targeted therapies for cardiovascular diseases through a precision medicine approach to drug development. ARCA’s lead product candidate, GencaroTM (bucindolol hydrochloride), is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and confirmed heart failure with reduced left ventricular ejection fraction (HFrEF) which recently completed a angle 2B clinical trial. ARCA has identified common genetic variations that it believes foretell individual patient response to Gencaro, giving it the potential to breathe the first genetically-targeted AF prevention treatment. ARCA has a collaboration with Medtronic, Inc. for support of the GENETIC-AF trial. The Gencaro progress program has been granted rapid Track designation by FDA. ARCA is also developing AB171, a thiol-substituted isosorbide mononitrate, as a potential genetically-targeted treatment for peripheral arterial disease (PAD) and for heart failure (HF). For more information, gratify visit www.arcabio.com.

    Story Continues

    Safe Harbor Statement

    This press release contains "forward-looking statements" for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements regarding the capacity of ARCA’s fiscal resources to support its operations through the End of the first quarter of 2019, potential future progress plans for Gencaro, the expected features and characteristics of Gencaro or AB171, including the potential for genetic variations to foretell individual patient response to Gencaro, Gencaro’s potential to handle AF, AB171’s potential to handle HF, future treatment options for patients with AF, and the potential for Gencaro to breathe the first genetically-targeted AF prevention treatment. Such statements are based on management's current expectations and involve risks and uncertainties.  Actual results and performance could disagree materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, the risks and uncertainties associated with: ARCA’s fiscal resources and whether they will breathe enough to meet its business objectives and operational requirements; ARCA may not breathe able to raise enough capital on acceptable terms, or at all, to continue progress of Gencaro or to otherwise continue operations in the future; results of earlier clinical trials may not breathe confirmed in future trials; the protection and market exclusivity provided by ARCA’s intellectual property; risks related to the drug discovery and the regulatory approval process; and, the impact of competitive products and technological changes.  These and other factors are identified and described in more detail in ARCA’s filings with the Securities and Exchange Commission, including without limitation ARCA’s annual report on contour 10-K for the year ended December 31, 2017, and subsequent filings. ARCA disclaims any intent or duty to update these forward-looking statements.

    Investor & Media Contact:Derek Cole720.940.2163derek.cole@arcabio.com

    (Tables follow)

      ARCA BIOPHARMA, INC.   BALANCE SHEET DATA  (in thousands)  (unaudited)     June 30, 2018   December 31, 2017 Cash, cash equivalents & marketable securities $9,635   $11,752 Working capital $8,950   $10,229 Total assets $10,067   $12,365 Total stockholders’ equity $8,998   $10,275        

     

        ARCA BIOPHARMA, INC.       STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS   (unaudited)         Three Months Ended     Six Months Ended     June 30,     June 30,     2018     2017     2018     2017                                     (in thousands, except partake and per partake amounts)   Costs and expenses:                               Research and development $ 1,154     $ 4,508     $ 2,874     $ 7,754   General and administrative   1,002       1,051       2,055       2,186   Total costs and expenses   2,156       5,559       4,929       9,940   Loss from operations   (2,156 )     (5,559 )     (4,929 )     (9,940 )                                 Interest and other income   43       39       84       84   Interest expense   (3 )     (2 )     (6 )     (4 ) Net loss $ (2,116 )   $ (5,522 )   $ (4,851 )   $ (9,860 )                                 Change in unrealized loss on marketable securities   —       4       2       14   Comprehensive loss $ (2,116 )   $ (5,518 )   $ (4,849 )   $ (9,846 )                                 Net loss per share:                               Basic and diluted $ (0.15 )   $ (0.59 )   $ (0.35 )   $ (1.07 ) Weighted middling shares outstanding:                               Basic and diluted   13,923,512       9,324,822       13,772,947       9,210,186                                  

    A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/af496e97-20da-420a-bf93-e51b3a3ed740



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    Operations & Process Management: Principles & Practice for Strategic ImpactOperations & Process Management: Principles & Practice for Strategic Impact
    By Nigel Slack, Alistair Jones
    Publisher : Pearson (Feb 2018)
    ISBN10 : 129217613X
    ISBN13 : 9781292176130
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    Subject : Business & Economics
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    Computer Security: Principles and PracticeComputer Security: Principles and Practice
    By William Stallings, Lawrie Brown
    Publisher : Pearson (Aug 2017)
    ISBN10 : 0134794109
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    Urban EconomicsUrban Economics
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    Urban EconomicsUrban Economics
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    Understanding BusinessUnderstanding Business
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    Publisher : McGraw-Hill (Feb 2018)
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    Understanding BusinessUnderstanding Business
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    Business Communication: Developing Leaders for a Networked WorldBusiness Communication: Developing Leaders for a Networked World
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    Business Communication: Developing Leaders for a Networked WorldBusiness Communication: Developing Leaders for a Networked World
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    Publisher : McGraw-Hill (Feb 2017)
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    Subject : Business & Economics, Communication & Media
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