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Showcase the HR leadership recognition you deserve with the Senior Professional in Human Resources® (SPHR®) from HR Certification Institute® (HRCI®). The SPHR demonstrates your mastery of the strategic and policy-making aspects of HR management as practiced in the U.S. The credential is designed for big-picture thinkers responsible for planning rather than implementing HR policy. Organizations seek out SPHR professionals for their proven accountability for HR department goals, for breadth and depth of knowledge in all HR disciplines, and for understanding business issues beyond the HR function.
Exam time: 3 hours
Exam length: 150 scored questions (mostly multiple-choice) + 25 pretest questions
Computer-based test at a Pearson VUE testing center
Leadership and Strategy (40%)
Talent Planning and Acquisition (16%)
Learning and Development (12%)
Total Rewards (12%)
Employee Relations and Engagement (20%)
01 Develop and execute HR plans that are aligned to the organizations strategic plan (for example: HR strategic plans, budgets, business plans, service delivery plans, HRIS, technology)
02 Evaluate the applicability of federal laws and regulations to organizational strategy (for example: policies, programs, practices, business expansion/reduction)
03 Analyze and assess organizational practices that impact operations and people management to decide on the best available risk management strategy (for example: avoidance, mitigation, acceptance)
04 Interpret and use business metrics to assess and drive achievement of strategic goals and objectives (for example: key performance indicators, financial statements, budgets)
05 Design and evaluate HR data indicators to inform strategic actions within the organization (for example: turnover rates, cost per hire, retention rates)
06 Evaluate credibility and relevance of external information to make decisions and recommendations (for example: salary data, management trends, published surveys and studies, legal/regulatory analysis)
07 Contribute to the development of the organizational strategy and planning (for example: vision, mission, values, ethical conduct)
08 Develop and manage workplace practices that are aligned with the organizations statements of vision, values, and ethics to shape and reinforce organizational culture
09 Design and manage effective change strategies to align organizational performance with the organizations strategic goals
10 Establish and manage effective relationships with key stakeholders to influence organizational behavior and outcomes
01 Vision, mission, and values of an organization and applicable legal and regulatory requirements
02 Strategic planning process
03 Management functions, including planning, organizing, directing, and controlling
04 Corporate governance procedures and compliance
05 Business elements of an organization (for example: products, competition, customers, technology, demographics, culture, processes, safety and security)
06 Third-party or vendor selection, contract negotiation, and management, including development of requests for proposals (RFPs)
07 Project management (for example: goals, timetables, deliverables, and procedures)
08 Technology to support HR activities
09 Budgeting, accounting, and financial concepts (for example: evaluating financial statements, budgets, accounting terms, and cost management)
10 Techniques and methods for organizational design (for example: outsourcing, shared services, organizational structures)
11 Methods of gathering data for strategic planning purposes (for example: Strengths, Weaknesses, Opportunities, and Threats [SWOT], and Political, Economic, Social, and Technological [PEST])
12 Qualitative and quantitative methods and tools used for analysis, interpretation, and decision making purposes
13 Change management processes and techniques
14 Techniques for forecasting, planning, and predicting the impact of HR activities and programs across functional areas
15 Risk management
16 How to deal with situations that are uncertain, unclear, or chaotic
01 Evaluate and forecast organizational needs throughout the business cycle to create or develop workforce plans (for example: corporate restructuring, workforce expansion, or reduction)
02 Develop, monitor, and assess recruitment strategies to attract desired talent (for example: labor market analysis, compensation strategies, selection process, onboarding, sourcing and branding strategy)
03 Develop and evaluate strategies for engaging new employees and managing cultural integrations (for example: new employee acculturation, downsizing, restructuring, mergers and acquisitions, divestitures, global expansion)
17 Planning techniques (for example: succession planning, forecasting)
18 Talent management practices and techniques (for example: selecting and assessing employees)
19 Recruitment sources and strategies
20 Staffing alternatives (for example: outsourcing, temporary employment)
21 Interviewing and selection techniques and strategies
22 Impact of total rewards on recruitment and retention
23 Termination approaches and strategies
24 Employee engagement strategies
25 Employer marketing and branding techniques
26 Negotiation skills and techniques
27 Due diligence processes (for example: mergers and acquisitions, divestitures)
28 Transition techniques for corporate restructuring, mergers and acquisitions, offshoring, and divestitures
29 Methods to assess past and future staffing effectiveness (for example: cost per hire, selection ratios, adverse impact)
01 Develop and evaluate training strategies (for example: modes of delivery, timing, content) to increase individual and organizational effectiveness
02 Analyze business needs to develop a succession plan for key roles (for example: identify talent, outline career progression, coaching and development) to promote business continuity
03 Develop and evaluate employee retention strategies and practices (for example: assessing talent, developing career paths, managing job movement within the organization)
30 Training program design and development
31 Adult learning processes
32 Training and facilitation techniques
33 Instructional design principles and processes (for example: needs analysis, content chunking, process flow mapping)
34 Techniques to assess training program effectiveness, including use of applicable metrics
35 Career and leadership development theories and applications
36 Organizational development (OD) methods, motivation methods, and problem-solving techniques
37 Coaching and mentoring techniques
38 Effective communication skills and strategies (for example: presentation, collaboration, sensitivity)
39 Employee retention strategies
40 Techniques to encourage creativity and innovation
01 Analyze and evaluate compensation strategies (for example: philosophy, classification, direct, indirect, incentives, bonuses, equity, executive compensation) that attract, reward, and retain talent
02 Analyze and evaluate benefit strategies (for example: health, welfare, retirement, recognition programs, work-life balance, wellness) that attract, reward, and retain talent
41 Compensation strategies and philosophy
42 Job analysis and evaluation methods
43 Job pricing and pay structures
44 External labor markets and economic factors
45 Executive compensation methods
46 Non-cash compensation methods
47 Benefits program strategies
48 Fiduciary responsibilities
49 Motivation concepts and applications
50 Benchmarking techniques
01 Design and evaluate strategies for employee satisfaction (for example: recognition, career path) and performance management (for example: performance evaluation, corrective action, coaching)
02 Analyze and evaluate strategies to promote diversity and inclusion
03 Evaluate employee safety and security strategies (for example: OSHA, HIPAA, emergency response plan, building access, data security/privacy)
04 Develop and evaluate labor strategies (for example: collective bargaining, grievance program, concerted activity, staying union free, strategically aligning with labor)
51 Strategies to facilitate positive employee relations
52 Methods for assessing employee attitudes, opinions, and satisfaction
53 Performance management strategies
54 Human relations concepts and applications
55 Ethical and professional standards
56 Diversity and inclusion concepts and applications
57 Occupational injury and illness prevention techniques
58 Workplace safety and security risks, and strategies
59 Emergency response, business continuity and disaster recovery strategies
60 Internal investigation, monitoring, and surveillance techniques
61 Data security and privacy
62 The collective bargaining process, strategies, and concepts (for example: contract negotiation, costing, administration)
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(GLOBE NEWSWIRE by the use of COMTEX) -- - according to unprecedented progression-free survival effects, Tafinlar (dabrafenib) + Mekinist (trametinib) tested as regular-of-care, focused remedy for advanced BRAF-mutated melanoma1-4
- facts display tremendous durable responses and progression-free survival advantage for sufferers handled with Tafinlar + Mekinist in the comparator arm of the COMBI-i clinical trial despite the study now not assembly the basic endpoint for the investigational triplet remedy
- Spartalizumab development application continues, investigating the immunotherapy in combination with different anti-melanoma brokers
Basel, September 19, 2020 -- Novartis introduced these days particular effects from the part III COMBI-i trial evaluating the investigational immunotherapy spartalizumab (PDR001) in combination with the targeted treatment options Tafinlar(R) (dabrafenib) and Mekinist(R) (trametinib) in comparison to Tafinlar + Mekinist alone1. The efficacy statistics accomplished within the trial's manage arm amongst patients treated with Tafinlar + Mekinist signify the longest progression-free survival consequences (PFS) followed across distinct section III studies. The trial didn't meet its simple endpoint of investigator-assessed progression-free survival (PFS) for sufferers handled with the investigational triplet therapy1-4.
The COMBI-i examine become conducted among medicine-naive patients with superior BRAF V600 mutation-effective cutaneous melanoma. effects have been introduced today as a late-breaking oral presentation all over the european Society of medical Oncology (ESMO) digital Congress 20201.
"For treating physicians and sufferers alike, the durable, development-free survival seen with dabrafenib + trametinib in COMBI-i confirms that this centered remedy mixture remains a gold commonplace medication for americans with advanced BRAF-mutated melanoma," referred to Dr. Paul Nathan, advisor clinical oncologist, Mount Vernon cancer Centre, uk, and COMBI-i foremost investigator. "The first rate information is that the handle arm of the examine carried out more suitable than they initially anticipated, with the efficacy of dabrafenib + trametinib improving perpetually over time. although the look at didn't meet its simple endpoint, a crucial style changed into viewed in choose of the triple remedy arm. there is naturally greater for us to study patients who may additionally advantage from the knowledge addition of an immunotherapy."
Findings from this randomized, double-blind, placebo-managed look at showed a median time of PFS of 16.2 months for patients treated with the triple therapy (n=267) compared to 12.0 months for patients receiving the mixture Tafinlar + Mekinist on my own (n=265; hazard ratio [HR] 0.eighty two; ninety five% CI 0.655-1.027; p=0.042)1. ordinary response expense turned into sixty eight.5% for spartalizumab with Tafinlar + Mekinist (95% CI, sixty two.6-seventy four.1%) in comparison to 64.2% for Tafinlar + Mekinist on my own (ninety five% CI, 58.1-69.9%)1. a big period of response (DOR) became seen within the analyze as median DOR for the triple therapy became not reached at two-year data cutoff, in comparison to 20.7 months with Tafinlar + Mekinist1.
"Working with their scientific investigator companions and melanoma patients worldwide, they undertook the COMBI-i analyze to be trained extra about how they can proceed to enhance affected person consequences, and they are proud that it superior the group's scientific realizing about knowledge triplet remedies," pointed out Jeff Legos, Ph.D., MBA, Senior vice president and Head of Oncology Drug development. "The examine effects beef up that patients taking Tafinlar + Mekinist proceed to peer durable responses and a significant development-free survival advantage, according to statistics said in previous phase III reviews."
"As they proceed to bring Tafinlar + Mekinist to sufferers everywhere, Novartis will proceed to increase the science with daring investigations into makes use of for immunotherapy in melanoma, together with the continued building of spartalizumab, across more than a few tumor kinds," Legos brought.
about the COMBI-i Study1
COMBI-i was a phase III, double-blinded global study (NCT02967692) evaluating the investigational anti-PD1 remedy spartalizumab in aggregate with Tafinlar + Mekinist compared to Tafinlar + Mekinist and placebo as first-line therapy in patients with unresectable (Stage IIIC) or metastatic (Stage IV) BRAF V600E/okay mutation-tremendous cutaneous melanoma. The examine became carried out in three parts. in the defense run-in (part 1), the fundamental endpoint became incidence of dose-limiting toxicities, and in the biomarker cohort (half 2), the primary endpoint became immune microenvironment and biomarker modulation. in the randomized component of the study (part 3), the primary endpoint changed into investigator-assessed progression-free survival.
COMBI-i examine members have been categorized as having both Stage IIIC (unresectable) or Stage IV (metastatic) sickness and obtained look at treatments as first-line therapy. No new facet consequences were seen and the security profile in the control arm turned into according to what has been followed in outdated experiences. COMBI-i additionally evaluated a brand new side impact administration protocol to handle pyrexia - or fever - a standard facet effect seen amongst centered cures.
severe treatment-linked opposed activities (TRAEs) grade greater-than or equal to3 took place in 23.2% of sufferers in the triple therapy arm compared to eleven% within the Tafinlar + Mekinist arm. the most general grade improved-than or equal to3 adversarial activities impartial of remedy relationship accompanied in the triple therapy and Tafinlar + Mekinist arms were blood creatine phosphokinase enhance (7.9% vs 7.2%), pyrexia (5.2% vs 3.0%), aspartate aminotransferase increase (three.7% vs 1.1%), fatigue (three.4% vs 1.9%), rash (three.4% vs 0.4%), asthenia (2.2% vs. 1.1%), headache (1.1% vs. 1.5%), diarrhea (0.7% vs. 1.9%), nausea (0.7% vs 0.4), arthralgia (0.7% vs 1.5%), and chills (zero vs. 0.8%). TRAEs leading to discontinuation of all 3 study drugs came about in 12% in comparison to 8% of sufferers, respectively.
seek advice from https://www.virtualcongress.novartis.com/esmo20/ for the latest suggestions from Novartis including their daring strategy to reimagining melanoma care, and entry to their ESMO digital Congress 2020 symposia and data presentations (for registered individuals).
About Spartalizumab (PDR001)
Spartalizumab is an investigational monoclonal antibody directed in opposition t the human programmed loss of life-1 (PD-1) receptor. Its construction application continues, investigating the immunotherapy across various tumor varieties.
About Tafinlar + Mekinist2-4
The mixture of the centered treatment plans Tafinlar + Mekinist, the worldwide chief in BRAF/MEK-inhibition, is authorised for the remedy of sufferers with unresectable or metastatic BRAF-mutated melanoma through the U.S. meals and Drug Administration (FDA) and European fee based on statistics from the pivotal part III COMBI-d and COMBI-v trials.
In COMBI-d, Tafinlar + Mekinist done a statistically gigantic usual survival (OS) improvement compared to Tafinlar monotherapy (median of 25.1 months vs 18.7 months; Hazard Ratio [HR] 0.seventy one [95% Confidence Interval (CI), 0.55-0.92], p=0.01). The median progression-free survival (PFS) became 9.three months in the 211 sufferers receiving aggregate therapy in comparison to 8.8 months in the 212 patients receiving monotherapy (HR 0.seventy five [95% CI, 0.57-0.99], p=0.035).
In COMBI-v, Tafinlar + Mekinist tested a statistically large OS advantage compared to vemurafenib monotherapy (median now not reached vs 17.2 months; HR 0.69 [95% CI, 0.53-0.89], p=0.005). The median PFS become eleven.four months within the 352 patients receiving the Tafinlar + Mekinist combination in comparison to 7.3 months in the 352 patients receiving vemurafenib monotherapy (HR 0.fifty six [95% CI, 0.46-0.69], p<0.001).
Tafinlar + Mekinist Indication and demanding defense counsel
Tafinlar and Mekinist are prescription drugs that can also be utilized in aggregate to treat individuals with a type of dermis cancer referred to as melanoma:
- That has unfold to different components of the body (metastatic) or can't be eliminated by means of surgery (unresectable), and
- That has a definite class of abnormal "BRAF" (V600E or V600K mutation-effective) gene
Tafinlar and Mekinist are prescription drugs that can also be utilized in combination to aid prevent melanoma that has a certain classification of irregular "BRAF" gene from coming again after the melanoma has been eliminated with the aid of surgical procedure.
Tafinlar and Mekinist are prescription medications that may also be utilized in combination to treat a sort of lung cancer known as non-small cell lung melanoma (NSCLC) that has spread to other elements of the body (metastatic NSCLC), and that has a certain class of abnormal "BRAF V600E" gene.
Tafinlar and Mekinist are prescription medicines that can also be utilized in combination to deal with a sort of thyroid melanoma called anaplastic thyroid cancer (ATC):
- That has unfold to different components of the physique and you have no adequate medication alternatives, and
- That has a undeniable type of irregular "BRAF" gene
Tafinlar, in aggregate with Mekinist, should still no longer be used to deal with people with wild-category BRAF melanoma. Mekinist should still not be used to deal with individuals who have already got obtained a BRAF inhibitor for medication of their melanoma and it did not work or is no longer working.
Your physician will function a look at various to be sure that Tafinlar and Mekinist, in mixture, are correct for you.
It is not standard if Tafinlar and Mekinist are protected and useful in toddlers.
Tafinlar and Mekinist, in mixture, could cause serious side outcomes such as the possibility of latest cancers, including both epidermis melanoma and nonskin cancer. patients should be informed to contact their health care professional automatically for any skin adjustments, together with a new wart, dermis sore, or bump that bleeds or doesn't heal, or a change within the size or color of a mole.
When Tafinlar is used in aggregate with Mekinist, it can cause serious bleeding complications, principally within the brain or abdominal, that can result in loss of life. patients may still be informed to name their medical professional and get clinical aid appropriate away in the event that they have any signals of bleeding, together with headaches, dizziness, or believe weak, cough up blood or blood clots, vomit blood or their vomit seems like "coffee grounds," or crimson or black stools that seem like tar.
Mekinist, by myself or in mixture with Tafinlar, may cause inflammation of the intestines or tears within the stomach or intestines that may result in death. patients may still document to their medical professional immediately in the event that they have any of here indicators: bleeding, diarrhea (unfastened stools) or extra bowel actions than average, stomach-area (abdomen) pain or tenderness, fever, or nausea.
Tafinlar, in aggregate with Mekinist, may cause blood clots in the palms or legs, that may travel to the lungs and can cause death. sufferers should still be informed to get clinical help appropriate away in the event that they have right here indicators: chest pain, surprising shortness of breath or hindrance respiratory, pain of their legs with or without swelling, swelling in their arms or legs, or a groovy or light arm or leg.
The aggregate of Tafinlar and Mekinist may cause heart problems, together with coronary heart failure. A affected person's coronary heart function should still be checked before and during medication. patients may still be suggested to name their health care professional appropriate away if they have any of the following signs and symptoms of a heart difficulty: feeling like their coronary heart is pounding or racing, shortness of breath, swelling of their ankles and feet, or feeling lightheaded.
Tafinlar, in combination with Mekinist, can cause severe eye complications that can result in blindness. patients may still be informed to call their surgeon right away in the event that they get: blurred vision, lack of imaginative and prescient, or other imaginative and prescient alterations, seeing color dots, halo (seeing blurred define around objects), eye ache, swelling, or redness.
Tafinlar, in combination with Mekinist, can cause lung or breathing issues. patients should still be counseled to inform their health care provider in the event that they have new or worsening signs of lung or respiration issues, including shortness of breath or cough.
Fever is usual all through medication with Tafinlar in aggregate with Mekinist, but may even be critical. In some situations, chills or shaking chills, too an awful lot fluid loss (dehydration), low blood force, dizziness, or kidney issues may additionally ensue with the fever. patients should be recommended to name their surgeon right away if they get a fever.
Rash and other dermis reactions are general aspect consequences of Tafinlar in aggregate with Mekinist. In some cases, these rashes and other dermis reactions can also be severe or severe, may need to be handled in a health center, or cause dying. sufferers may still be advised to name their health professional in the event that they get any of the following signs: blisters or peeling of skin, mouth sores, blisters on the lips or across the mouth or eyes, high fever or flu-like symptoms, and/or enlarged lymph nodes.
Some people may additionally enhance high blood sugar or worsening diabetes during medication with Tafinlar in combination with Mekinist. For patients who are diabetic, their health professional should still verify their blood sugar degrees closely throughout remedy. Their diabetes drugs could need to be changed. sufferers should be counseled to tell their doctor if they have multiplied thirst, urinate extra regularly than normal, or produce an increased volume of urine.
Tafinlar may cause suit red blood cells to break down too early in americans with glucose-6-phosphate dehydrogenase deficiency. This can also result in a kind of anemia referred to as hemolytic anemia, the place the body doesn't have adequate healthy crimson blood cells. sufferers may still be counseled to tell their general practitioner in the event that they have yellow skin (jaundice), weakness or dizziness, or shortness of breath.
Tafinlar, in aggregate with Mekinist, may cause new or worsening excessive blood drive (hypertension). A patient's blood power may still be checked all over remedy. sufferers may still be informed to inform their health care provider if they strengthen excessive blood drive, their blood drive worsens, or if they have severe headache, lightheadedness, blurry imaginative and prescient, or dizziness.
guys (including those that have had a vasectomy) should still use condoms during sexual intercourse right through medication with Tafinlar and Mekinist and for at the least four months after the ultimate dose of Tafinlar and Mekinist. for women of reproductive advantage, Tafinlar and Mekinist, in aggregate, can also hurt your unborn child. Use positive contraception (contraception) all the way through medication with Tafinlar and Mekinist in combination, and for four months after stopping medication with Tafinlar and Mekinist. the most common aspect effects for patients with metastatic melanoma are: pyrexia, nausea, rash, chills, diarrhea, headache, vomiting, hypertension, arthralgia, peripheral edema, and cough. the most common side outcomes for patients with stage III melanoma receiving the aggregate as adjuvant therapy are: pyrexia, fatigue, nausea, headache, rash, chills, diarrhea, vomiting, arthralgia, and myalgia. essentially the most usual facet consequences for patients with NSCLC: pyrexia, fatigue, nausea, vomiting, diarrhea, dry dermis, lowered appetite, edema, rash, chills, hemorrhage, cough, and dyspnea.
Please see full Prescribing tips for Tafinlar at https://www.novartis.us/websites/www.novartis.us/information/tafinlar.pdf
and Mekinist at https://www.novartis.us/sites/www.novartis.us/info/mekinist.pdf.
This press release consists of forward-searching statements within the which means of the united states inner most Securities Litigation Reform Act of 1995. ahead-searching statements can commonly be recognized by way of words similar to "competencies," "can," "will," "plan," "can also," "might," "would," "expect," "expect," "are seeking," "appear ahead," "consider," "committed," "investigational," "pipeline," "launch," or equivalent terms, or by express or implied discussions regarding expertise advertising approvals, new indications or labeling for the investigational or authorised items described during this press unencumber, or regarding skills future revenues from such products. remember to no longer vicinity undue reliance on these statements. Such ahead-looking statements are based on their latest beliefs and expectations involving future pursuits, and are field to big widely used and unknown hazards and uncertainties. should one or greater of those dangers or uncertainties materialize, or may still underlying assumptions show unsuitable, exact outcomes may also range materially from these set forth within the ahead-looking statements. There will also be no make certain that the investigational or permitted items described during this press unencumber may be submitted or approved on the market or for any additional indications or labeling in any market, or at any certain time. Nor can there be any make certain that such items can be commercially a success sooner or later. In particular, their expectations involving such products can be affected by, amongst different things, the uncertainties inherent in analysis and construction, including scientific trial outcomes and additional evaluation of current medical records; regulatory movements or delays or government rules commonly; international tendencies toward fitness care charge containment, together with govt, payor and typical public pricing and reimbursement pressures and necessities for increased pricing transparency; their skill to gain or maintain proprietary highbrow property coverage; the specific prescribing preferences of physicians and sufferers; standard political, economic and enterprise circumstances, together with the consequences of and efforts to mitigate pandemic diseases akin to COVID-19; safeguard, high-quality, information integrity or manufacturing concerns; abilities or genuine statistics safety and information privateness breaches, or disruptions of their assistance technology programs, and different hazards and factors stated in Novartis AG's current kind 20-F on file with the U.S. Securities and trade commission. Novartis is proposing the counsel in this press release as of this date and doesn't undertake any obligation to update any ahead-searching statements contained in this press free up as a result of new tips, future routine or in any other case.
Novartis is reimagining medicine to Strengthen and extend americans's lives. As a leading world drugs company, they use ingenious science and digital technologies to create transformative remedies in areas of splendid scientific want. In their quest to locate new medicines, they invariably rank among the world's excellent corporations investing in research and development. Novartis products reach very nearly 800 million people globally and we're finding imaginative tips on how to extend access to their latest treatments. About 109,000 people of more than a hundred and forty nationalities work at Novartis everywhere. find out extra at https://www.novartis.com.
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- Nathan P, et al. Spartalizumab plus dabrafenib and trametinib in patients with up to now untreated BRAF V600-mutant unresectable or metastatic melanoma: outcomes from the randomized half three of the phase III COMBI-i trial. Presentation number LBA43. ESMO virtual Congress 2020, September 19-21, 2020.
- Robert C, et al. five-yr results with Dabrafenib plus Trametinib in Metastatic Melanoma. N Engl J Med. 2019 June 4. doi: 10.1056/NEJMoa1904059.
- TAFINLAR(R) (dabrafenib) Prescribing assistance. Novartis pharmaceuticals supplier, April 2020. available at: https://www.novartis.us/sites/www.novartis.us/information/tafinlar.pdf.
- MEKINIST(R) (trametinib) Prescribing assistance. Novartis prescription drugs organization, April 2020. obtainable at: https://www.novartis.us/sites/www.novartis.us/data/mekinist.pdf.
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